The studies of drugs that could constitute a palliative to spinal cord injury (SCI) are a continuous and increasing demand in\nbiomedicine field from developed societies. Recently we described the chemical synthesis and antiglioma activity of synthetic\nglycosides. A synthetic sulfated glycolipid (here IG20) has shown chemical stability, solubility in polar solvents, and high inhibitory\ncapacity over glioma growth. We have used mass spectrometry (MS) to monitor IG20 (????/???? = 550.3) in cells and tissues of the\ncentral nervous system (CNS) that are involved in SCI recovery. IG20 was detected by MS in serum and homogenates from CNS\ntissue of rats, though in the latter a previous deproteinization step was required.The pharmacokinetic parameters of serum clearance\nat 24 h and half-life at 4 h were determined for synthetic glycoside in the adult rat using MS. A local administration of the drug\nnear of spinal lesion site is proposed.
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